THE EVOLUTION OF CYBERSECURITY: ASSESSING THE EFFECTIVENESS OF LEGAL FRAMEWORKS IN THE FACE OF EMERGING TECHNOLOGIES AND TRANSNATIONAL CYBER ATTACKS

This research article aims to examine the impact of emerging technologies on cybersecurity and evaluate the effectiveness of legal frameworks in addressing transnational cyber-attacks. With the rapid advancement of technology, cyber threats have become more sophisticated and interconnected, requiring robust legal measures to combat them. With the emergence of new technologies, the threat landscape for cyber security has also evolved. The continuous development of new technologies like (A.I) artificial intelligence, (I.O.T) Internet of Things & cloud computing has led to a rapid increase in cyber-attacks and has made it even more challenging for organizations to protect their assets. This study utilizes a mixed-methods approach, incorporating both qualitative and quantitative research methods. The qualitative aspect involves an analysis of existing literature, case studies, and legal frameworks, while the quantitative component includes surveys and interviews with cybersecurity professionals and legal experts. By integrating these methods, this research aims to provide valuable insights into the effectiveness of current legal measures in mitigating transnational cyber-attacks and propose strategies to enhance cybersecurity in the face of emerging technologies.

Quais as consequências da aprovação do novo arcabouço fiscal para o SUS? / What are the implicationsof the adoptionof the new fiscal framework for the Brazilian Unified Health System? / ¿Cuáles son los efectosde la aprobación del nuevo marco fiscal para el Sistema Único de Salud del Brasil?

Quais as consequências da aprovação do novo arcabouço fiscal para o Sistema Único de Saúde (SUS)? Esta é a pergunta que norteia este editorial que reflete, com base em estudos econômicos e normativas federais, a necessidade de aprovação de um arcabouço fiscal que dialogue com um projeto de sistema universal de saúde, não desconsiderando o contexto histórico de desfinanciamento estrutural do SUS frente aos seus princípios, objetivos e diretrizes sistematizados pela nossa Constituição Federal.

What are the implications of the approval of the new fiscal framework for the Brazilian Unified Health System (SUS)? This question is the focus this editorial, which, based on economic studies and federal regulations, reflects the need to approve a fiscal framework consistent with the project of auniversal health system, not ignoring the historical context of structural underfunding of the SUS given its principles, objectives and guidelines systematized in Brazilian Federal Constitution.

¿Cuáles son los efectos de la aprobación del nuevo marco fiscal para el Sistema Único de Salud (SUS) del Brasil? Esa es la pregunta que guía este editorial, que refleja, con base en estudios económicos y normas federales, la necesidad de aprobar un marco fiscal que dialogue con un proyecto de sistema universal de salud, sin olvidar el contexto histórico de desfinanciamiento estructural del SUS frente de sus principios, objetivos y lineamientos sistematizados por la Constitución Federal de Brasil.

Writing A Research Framework For An Evaluation Of The Effectiveness Of Sustainable Tourism Policy Implementation In Cambodia: A Case Of Angkor World Heritage Area

This article aims at writing a research framework for exploring sustainable cultural heritage tourism policy implementation at Angkor (World Heritage Area). There are six policy initiatives within Angkor's Tourism Management Plan (2012-2020) to guide sustainability of tourism development. The year 2020 was the end of implementing these policy initiatives, but there were not any documents reporting the effectiveness and success of their implementations; therefore, this study will show the framework for investigating the implementation of policy initiatives within this timeframe. There are three main objectives in this framework. First, it is necessary to identify the outcomes of policy implementation judged by stakeholders. Second, it is important to outline and understand the barriers that hinder the successful implementation of the policy. Third, there is a need to create a framework for how to successfully implement sustainable tourism policies in the development of more sustainable tourism in the future.

A chiral metal-organic framework {(HQA)(ZnCl2)(2.5H2O)}n for the enantioseparation of chiral amino acids and drugs / 药物分析学报

Chiral metal-organic frameworks(CMOFs)with enantiomeric subunits have been employed in chiral chemistry.In this study,a CMOF formed from 6-methoxyl-(8S,9R)-cinchonan-9-ol-3-carboxylic acid(HQA)and ZnCl2,{(HQA)(ZnCl2)(2.5H2O)｝n was constructed as a chiral stationary phase(CSP)via an in situ fabrication approach and used for chiral amino acid and drug analyses for the first time.The{(HQA)(ZnCl2)(2.5H2O)}n nanocrystal and the corresponding chiral stationary phase were systematically characterised using a series of analytical techniques including scanning electron microscopy,X-ray diffraction,Fourier transform infrared spectroscopy,circular dichroism,X-ray photoelectron spectros-copy,thermogravimetric analysis,and Brunauer-Emmett-Teller surface area measurements.In open-tubular capillary electrochromatography(CEC),the novel chiral column exhibited strong and broad enantioselectivity toward a variety of chiral analytes,including 19 racemic dansyl amino acids and several model chiral drugs(both acidic and basic).The chiral CEC conditions were optimised,and the enantioseparation mechanisms are discussed.This study not only introduces a new high-efficiency member of the MOF-type CSP family but also demonstrates the potential of improving the enantiose-lectivities of traditional chiral recognition reagents by fully using the inherent characteristics of porous organic frameworks.

Immobilizing engineered Escherichia coli cells into zeolitic imidazolate framework 8 for efficient biosynthesis of Ala-Gln / 生物工程学报

The α-amino acid ester acyltransferase (SAET) from Sphingobacterium siyangensis is one of the enzymes with the highest catalytic ability for the biosynthesis of l-alanyl-l-glutamine (Ala-Gln) with unprotected l-alanine methylester and l-glutamine. To improve the catalytic performance of SAET, a one-step method was used to rapidly prepare the immobilized cells (SAET@ZIF-8) in the aqueous system. The engineered Escherichia coli (E. coli) expressing SAET was encapsulated into the imidazole framework structure of metal organic zeolite (ZIF-8). Subsequently, the obtained SAET@ZIF-8 was characterized, and the catalytic activity, reusability and storage stability were also investigated. Results showed that the morphology of the prepared SAET@ZIF-8 nanoparticles was basically the same as that of the standard ZIF-8 materials reported in literature, and the introduction of cells did not significantly change the morphology of ZIF-8. After repeated use for 7 times, SAET@ZIF-8 could still retain 67% of the initial catalytic activity. Maintained at room temperature for 4 days, 50% of the original catalytic activity of SAET@ZIF-8 could be retained, indicating that SAET@ZIF-8 has good stability for reuse and storage. When used in the biosynthesis of Ala-Gln, the final concentration of Ala-Gln reached 62.83 mmol/L (13.65 g/L) after 30 min, the yield reached 0.455 g/(L·min), and the conversion rate relative to glutamine was 62.83%. All these results suggested that the preparation of SAET@ZIF-8 is an efficient strategy for the biosynthesis of Ala-Gln.

Pressupostos epistemológicos das cidades amigas das pessoas idosas: revisão de escopo / Presupuestos epistemológicos de las ciudades amigables con las personas mayores: revisión de alcance / Epistemological assumptions of age-friendly cities: a scoping review

Resumo Objetivo Identificar os conceitos e perspectivas teóricas que fundamentam os estudos sobre Cidade Amiga da Pessoa Idosa. Métodos Revisão de escopo utilizando seis bancos de dados para identificar estudos publicados em revistas indexadas entre 2007 e 2021 usando as palavras-chave 'age-friendly' OR 'age friendly' OR 'cidade amiga'. Resultados Foram encontrados 2.975 estudos que após aplicação de critérios de exclusão resultaram em 227. Observou-se ampla variação no conceito do termo, porém muitos autores o fizeram replicando a OMS, sendo que em 59,5% dos estudos não houve menção de nenhuma perspectiva teórica. A teoria ecológica foi o referencial mais frequente (26%), sendo o termo usado como um equivalente a envelhecimento ativo. Autores de quatro países respondem pela maioria dos artigos (61%). Conclusão É necessário articular o conceito de Cidade Amiga da Pessoa Idosa com uma abordagem teórica e cultural para compreender mais profundamente as perspectivas do urbano e do social sob a lógica do envelhecimento populacional principalmente para a América Latina. A análise teórica nestes estudos e na gerontologia favorecerão discussões mais críticas sobre o envelhecimento, o idadismo e a crescente desigualdade social em curso.

Resumen Objetivo Identificar los conceptos y perspectivas teóricas que fundamentan los estudios sobre Cuidades Amigables con las Personas Mayores. Métodos Revisión de alcance utilizando seis bancos de datos para identificar estudios publicados en revistas indexadas entre 2007 y 2021, con las palabras clave 'age-friendly' OR 'age friendly' OR 'ciudad amigable'. Resultados Se encontraron 2975 estudios que, luego de aplicar los criterios de exclusión, quedaron 227. Se observó una amplia variación del concepto del término, aunque muchos autores replicaron a la OMS. En el 59,5 % de los estudios no se mencionó ninguna perspectiva teórica. La teoría ecológica fue la referencia más frecuente (26 %), y el término se usó como un equivalente al envejecimiento activo. La mayoría de los artículos (61 %) son de autores de cuatro países. Conclusión Es necesario unir el concepto de Cuidades Amigables con las Personas Mayores con un enfoque teórico y cultural para comprender más profundamente las perspectivas de lo urbano y lo social de acuerdo con la lógica del envejecimiento poblacional, principalmente en América Latina. El análisis teórico en estos estudios y en la gerontología permitirán discusiones más críticas sobre el envejecimiento, el edadismo y la creciente desigualdad social en curso.

Abstract Objective To identify the concepts and theoretical perspectives that underlie studies on age-friendly city. Methods This is a scoping review using six databases to identify studies published in indexed journals between 2007 and 2021 using the keywords 'age-friendly' OR 'age friendly' OR 'cidade amiga'. Results A total of 2,975 studies were found, which, after applying the exclusion criteria, resulted in 227. There was wide variation in the concept of the term, but many authors did so by replicating the WHO, and in 59.5% of studies there was no mention of any theoretical perspective. The ecological theory was the most frequent reference (26%), the term being used as an equivalent to active aging. Authors from four countries account for most articles (61%). Conclusion It is necessary to articulate the concept of age-friendly city with a theoretical and cultural approach to understand more deeply the urban and social perspectives under the logic of population aging, mainly for Latin America. Theoretical analysis in these studies and in gerontology will favor more critical discussions about aging, ageism and the growing social inequality in progress.

La interseccionalidad como herramienta teórico-analítica para estudiar las desigualdades en salud en las Américas / Intersectionality as a theoretical-analytical tool to study health inequalities in the Americas / A interseccionalidade como ferramenta teórico-analítica para estudo das desigualdades em saúde nas Américas

RESUMEN Objetivo. Analizar las desigualdades en la salud autopercibida entre grupos de población situados en las intersecciones de identidad de género, grupo étnico y nivel de educación en países de las Américas, clasificados según su nivel de ingreso. Métodos. Se utilizaron datos en panel de la Encuesta Mundial de Valores en el período comprendido entre los años 1990 y 2022. La muestra de este estudio incluyó 58 790 personas entre 16 y 65 años, provenientes de 14 países del continente americano. La variable dependiente fue la mala salud autopercibida, las variables independientes fueron el género, el nivel de educación y el grupo étnico. Para el análisis interseccional intercategórico se creó una variable multicategórica de 12 estratos. Se realizó un análisis de heterogeneidad individual y precisión diagnóstica mediante cinco modelos de regresión logística ajustados por edad y ola de encuesta. Resultados. Se observó un claro y persistente gradiente interseccional para la mala salud autopercibida en todas las desagregaciones de países por su ingreso. Comparados con la categoría más aventajada (hombres de etnia mayoritaria y educación superior), los demás grupos incrementaron el riesgo de mala salud, con el mayor riesgo en las mujeres de etnia minoritaria o pueblos indígenas con nivel de educación inferior a secundaria (tres a cuatro veces mayor). Además, las mujeres tuvieron mayor riesgo de mala salud respecto a los hombres en cada uno de los pares de estratos interseccionales. Conclusiones. El análisis interseccional demostró la persistencia de un gradiente social de la mala salud autopercibida en el continente americano.

ABSTRACT Objective. Analyze inequalities in self-perceived health among population groups located at the intersections of gender identity, ethnicity, and education level in countries of the Americas, classified by income level. Methods. Panel data from the World Values Survey were used for the period 1990-2022. The study sample included 58 790 people between 16 and 65 years of age from 14 countries in the Americas. The dependent variable was poor self-perceived health, and the independent variables were gender, education level, and ethnicity. A multi-categorical variable with 12 strata was created for the intercategorical intersectionality analysis. An analysis of individual heterogeneity and diagnostic accuracy was performed using five logistic regression models, adjusted by age and by survey wave. Results. A clear and persistent intersectional gradient for poor self-perceived health was observed in all country disaggregations by income. Compared to the category with the most advantage (men of majority ethnicity and higher education), the other groups had increased risk of poor health, with the highest risk among women of minority ethnicity and in Indigenous peoples with less than secondary education (three to four times higher). In addition, women had a higher risk of poor health than men in each pair of intersectional strata. Conclusions. The intersectional analysis demonstrated a persistent social gradient of self-perceived ill health in the Americas.

RESUMO Objetivo. Analisar desigualdades na autopercepção de saúde entre grupos populacionais localizados nas interseções de identidade de gênero, etnia e nível de escolaridade em países das Américas, classificados pelo nível de renda. Métodos. Foram usados dados em painel da Pesquisa Mundial de Valores referentes ao período de 1990 a 2022. A amostra deste estudo incluiu 58 790 pessoas com idades entre 16 e 65 anos de 14 países das Américas. A variável dependente foi a autopercepção de problemas de saúde, e as variáveis independentes foram gênero, nível de escolaridade e etnia. Para a análise interseccional intercategórica, foi criada uma variável multicategórica de 12 estratos. Foi realizada uma análise da heterogeneidade individual e da precisão do diagnóstico usando cinco modelos de regressão logística ajustados por idade e onda de pesquisa. Resultados. Observou-se um gradiente interseccional claro e persistente para a autopercepção de problemas de saúde em todas as desagregações de países por renda. Em comparação com a categoria mais favorecida (homens de etnia majoritária e com ensino superior), todos os outros grupos apresentaram maior risco de problemas de saúde, com o maior risco para mulheres de etnias minoritárias ou povos indígenas com nível de escolaridade inferior ao ensino médio (três a quatro vezes maior). Além disso, as mulheres tinham um risco maior de problemas de saúde do que os homens em cada um dos pares de estratos interseccionais. Conclusões. A análise interseccional demonstrou a persistência de um gradiente social na autopercepção de problemas de saúde nas Américas.

Intersectionality Theory, Challenges for Empirical Research and Contributions to Psychology / Teoria da Interseccionalidade, Desafios para Pesquisas Empíricas e Contribuições para a Psicologia / Teoría de la Interseccionalidad, Desafíos para la Investigación Empírica y Aportes a la Psicología

Abstract The Theory of Intersectionality is an important contribution from feminist epistemologies to the scientific field. This narrative literature review aims to discuss methodological possibilities and challenges in producing and analyzing empirical evidence based on the Theory of Intersectionality, as well as its contributions to Psychology. While this theory is increasingly being cited as the basis for empirical research, articulating its assumptions in knowledge production processes is still a difficulty. Qualitative approaches prevail in the field, but advancements in statistical analysis methods allow for an intersectional interpretation in quantitative studies. Intersectionality contributes to understanding psychological processes and challenging dominant and exclusionary assumptions in the field of Psychology. Embracing this theory requires a commitment to the imperative of social transformation and entails placing claims, values, practices, and power relations at the core of scientific knowledge production, regardless of the field under study.

Resumo A Teoria da Interseccionalidade é uma importante contribuição das epistemologias feministas para o campo científico. Este estudo de revisão narrativa da literatura teve como objetivo discutir possibilidades e desafios metodológicos na produção e análise de evidências empíricas embasadas na Teoria da Interseccionalidade e suas contribuições para a Psicologia. Embora essa teoria esteja crescentemente sendo citada como base de pesquisas empíricas, ainda se identifica a dificuldade de articular seus pressupostos nos processos de produção de conhecimento. As abordagens qualitativas são predominantes no campo e observa-se avanços em métodos de análises estatísticas que permitem uma leitura interseccional em estudos quantitativos. A interseccionalidade contribui para compreender processos psicológicos e desafiar suposições dominantes e excludentes no campo da Psicologia. Adotar essa teoria requer uma implicação com o imperativo de transformação social e implica tornar reivindicações, valores, práticas e relações de poder como cerne da produção de conhecimento científico, independentemente do campo estudado.

Resumen La Interseccionalidad es una importante contribución de las epistemologías feministas al campo científico. Este artículo de revisión narrativa tiene como objetivo discutir las posibilidades y desafíos metodológicos en la producción y análisis de evidencia empírica basada en la Interseccionalidad y sus contribuciones a la Psicología. Aunque esta teoría se cita cada vez más como base de investigaciones empíricas, aún se identifica la dificultad de articular sus supuestos en los procesos de producción de conocimiento. Los enfoques cualitativos predominan en el campo y se observan avances en métodos de análisis estadístico que permiten una lectura interseccional en estudios cuantitativos. La interseccionalidad contribuye a comprender los procesos psicológicos y desafiar suposiciones dominantes y excluyentes en el campo de la Psicología. Adoptar esta teoría requiere una implicación con el imperativo de transformación social e implica poner las demandas, valores, prácticas y relaciones de poder en el centro de la producción de conocimiento científico, independientemente del campo estudiado.

Obesidade e interseccionalidade: análise crítica de narrativas no âmbito das políticas públicas de saúde no Brasil (2004-2021) / Obesity and intersectionality: critical analysis of narratives within public health policies in Brazil (2004-2021) / Obesidad e interseccionalidad: análisis crítico de narrativas en el ámbito de las políticas públicas de salud en Brasil (2004-2021)

Resumo: Objetivou-se realizar uma análise crítica da narrativa das políticas públicas de saúde brasileiras no cuidado da obesidade a partir de uma perspectiva interseccional. Trata-se de estudo qualitativo exploratório, documental e analítico, baseado na abordagem "What's the problem represented to be?" ["Qual é o problema representado para ser?"], conhecida como WPR. Tal abordagem se configura como uma ferramenta metodológica de análise crítica de políticas públicas a partir de seis perguntas norteadoras. Foram selecionados dez documentos, publicados entre 2004 a 2021 pelo governo brasileiro. A análise crítica resultou em três categorias: (i) causas da obesidade e narrativa dominante: quais são os problemas representados?; (ii) narrativa dominante e cuidado em saúde: quais são os efeitos para as pessoas com obesidade?; e (iii) obesidade e interseccionalidade: onde estão os silêncios? O consumo de alimentos e o sedentarismo foram a narrativa dominante como causas da obesidade. A interseccionalidade, mediada pelas categorias de gênero/sexo, raça/cor e classe social, foi identificada como um silêncio na narrativa das políticas públicas de saúde. Tais categorias não foram consideradas como causas atreladas à obesidade, tampouco foram incluídas de forma efetiva nas ações propostas pelas políticas públicas de saúde. Os silêncios encontrados no estudo destacam a necessidade de inclusão da interseccionalidade na elaboração e execução de políticas públicas de saúde e no cuidado das pessoas com obesidade. Tendo em vista as intersecções de gênero/sexo, raça/cor e classe social e suas formas de opressão com o surgimento e agravo da obesidade, são de extrema relevância análises críticas sobre as narrativas simplistas nas políticas públicas de saúde para problematização das lacunas que repercutem no cuidado dos usuários com obesidade.

Abstract: This study aimed to critically analyze the narrative of Brazilian public health policies in obesity care based on an intersectional approach. This is a qualitative exploratory, documentary, and analytical study based on the "What's the problem represented to be?" approach (WPR). This approach constitutes a methodological instrument for critical analysis of public policies based on six guiding questions. A total of ten documents were selected, published from 2004 to 2021 by the Brazilian government. The critical analysis resulted in three categories: (i) obesity causes and the dominant narrative: what problems are represented?; (ii) dominant narrative and health care: what are the effects for people with obesity?; (iii) obesity and intersectionality: where are silences? The consumption of food and sedentary lifestyle were the dominant narrative as causes of obesity. Intersectionality, mediated by the categories of gender/sex, race/skin-color, and social class, was identified as silenced in the narrative of public health policies, not being associated as linked causes of obesity, nor effectively included in the proposed actions of the policies. The silences found in the study highlight the need to include intersectionality in the elaboration and execution of public health policies and in the care of people with obesity. Considering the intersections of gender/sex, race/skin-color, and social class and their forms of oppression in the emergence and aggravation of obesity, critical analyses of simplistic narratives in public health policies are extremely relevant to problematize gaps affect the care of users with obesity.

Resumen: Este estudio tuvo como objetivo realizar un análisis crítico de la narrativa de las políticas públicas de salud brasileñas en el cuidado de la obesidad con base en un enfoque interseccional. Estudio cualitativo exploratorio, documental y analítico. Basado en el enfoque "Whats the problem represent to be?" [¿Cuál es el problema representado?], conocido como WPR. Tal enfoque se configura como una herramienta metodológica para el análisis crítico de las políticas públicas con base en seis preguntas rectoras. Se seleccionaron 10 documentos, publicados entre el 2004 y el 2021 por el gobierno brasileño. El análisis crítico resultó en tres categorías: (i) causas de la obesidad y la narrativa dominante: ¿Qué problemas se representan?; (ii) narrativa dominante y el cuidado en salud ¿Cuáles son los efectos para las personas con obesidad?; (iii) obesidad e interseccionalidad ¿Dónde están los silencios?. El consumo de alimentos y el sedentarismo fueron la narrativa dominante como causas de la obesidad. La interseccionalidad, mediada por las categorías de género/sexo, raza/color y clase social fue identificada como un silencio en la narrativa de las PPS, sin asociarlas como causas vinculadas a la obesidad ni incluirlas de forma efectiva en las acciones propuestas por las políticas públicas de salud. Los silencios encontrados en el estudio resaltan la necesidad de incluir la interseccionalidad en la elaboración y ejecución de las políticas públicas de salud y en el cuidado de las personas con obesidad. Considerando las intersecciones de género/sexo, raza/color y clase social y sus formas de opresión con el surgimiento y agravamiento de la obesidad, es sumamente relevante realizar análisis críticos sobre las narrativas simplistas en las políticas públicas de salud, para problematizar las brechas que repercuten en el cuidado de los usuarios con obesidad.

Redes de gobernanza intermunicipal: aplicación de modelos de grafos aleatorios exponenciales en la región de Los Lagos, Chile / Redes de governança intermunicipal: aplicação de modelos de gráficos aleatórios exponenciais em Los Lagos, Chile / Inter-municipal governance networks: application of exponential random graph models in Los Lagos, Chile

Resumen Desde los noventa, la idea de gobernanza ha permeado los debates acerca de la transformación del Estado a escala regional, sin embargo, las dificultades de su operacionalización han limitado nuestro conocimiento. Este artículo busca contribuir con esta brecha, examinando la dimensión interjurisdiccional de la gobernanza regional. Aplicando la perspectiva de análisis de redes, se estudia la formación de las redes intermunicipales que se configuran a partir de diferentes mecanismos de colaboración. Con base en el marco de acción colectiva institucional, el artículo analiza la prevalencia de estructuras de relacionamiento asociadas a diferentes tipos de capital social (bonding - capital social vínculo ‒ y bridging - capital social puente ‒) en tres redes intermunicipales de la región de Los Lagos, en Chile. Por medio de la aplicación de modelos de grafos aleatorios exponenciales (ERGM), se obtiene evidencia para sustentar la consistente prevalencia de bonding en las tres redes estudiadas y su coexistencia con estructuras descentralizadas en las redes de mayor complejidad regional.

Resumo Desde a década de noventa, a ideia de governança permeou os debates sobre a transformação do Estado no âmbito regional, não obstante, as dificuldades de sua operacionalização têm limitado nosso conhecimento. Este artigo busca contribuir para essa lacuna, examinando a dimensão interjurisdicional da governança regional. Aplicando a perspectiva da análise de redes, estuda-se a formação de redes intermunicipais que se configuram a partir de diferentes mecanismos de colaboração. Com base no marco institucional da ação coletiva, o artigo analisa a prevalência de estruturas de relacionamento associadas a diferentes tipos de capital social (bonding/bridging) em três redes intermunicipais da região de Los Lagos, no Chile. Através da aplicação de modelos de gráficos aleatórios exponenciais (ERGM), obtêm-se evidências que suportam a prevalência consistente de bonding nas três redes estudadas e sua coexistência com estruturas descentralizadas em redes de maior complexidade regional.

Abstract The idea of governance has permeated the debates on the state's transformation at the regional level since the 1990s. However, operationalization difficulties have limited our knowledge of the phenomenon. This article contributes to filling this gap by examining the inter-jurisdictional dimension of regional governance. From a network perspective, the article studies the emergence of inter-municipal networks from different local collaborative mechanisms. Based on the institutional collective action framework, the study analyzes the prevalence of network structures associated with different types of social capital (bonding/bridging) in three inter-municipal networks in the Los Lagos Region in Chile. The application of exponential random graph models (ERGM) revealed evidence supporting the consistent prevalence of bonding in the three networks studied. The findings also showed the networks' coexistence with structures decentralized in more complex regional networks.

Systematic construction of undergraduate curriculum for rehabilitation based on WHO rehabilitation competency framework / 中国康复理论与实践

ObjectiveTo systematically develop the courses of rehabilitation based on World Health Organization rehabilitation competency framework (RCF). MethodsThe theories and methods of RCF were used to analyze competency characteristics of rehabilitation workers and educational objectives to construct the curriculum contents in rehabilitation. ResultsThe competency of the rehabilitation workers included practice, professionalism, learning and development, management and leadership, research, values and beliefs in the specific rehabilitation situations. The objectives of rehabilitation medicine education needed to correspond to the competencies of the rehabilitation workers and set up knowledge units that could develop competency in terms of behaviour, activity tasks and proficiency. The curriculum systems of rehabilitation with RCF included the fields of rehabilitation physiotherapy, rehabilitation occupational therapy, hearing and speech rehabilitation, and prosthetic and orthopaedic engineering, etc. ConclusionThe teaching objectives corresponding to the competency characteristics of rehabilitation workers need to be translated into competency-based education. The curriculum contents in rehabilitation needs to be systematically constructed based on RCF from the areas of rehabilitation physiotherapy, rehabilitation occupational therapy, hearing and speech rehabilitation, and prosthetic and orthopaedic engineering.

Developing curriculum of speciality of education and rehabilitation using WHO rehabilitation competency framework / 中国康复理论与实践

ObjectiveTo construct rehabilitation competency framework (RCF) of the speciality of education and rehabilitation (SER-RCF) based on World Health Organization RCF, to innovate the curriculum system. MethodsThe competency for undergraduate level professionals in the speciality of education and rehabilitation were analyzed to develop curriculum using RCF theory and methodology. ResultsTalent training was a kind of competency-based and outcome-based education. SER-RCF integrated the competencies and activities in the areas of professionalism, practice, learning and development, management and leadership, and research required for professional work in education and rehabilitation around core values and beliefs. It also designed the training objectives of the speciality of education and rehabilitation: to be ethical and correct, to be physically and mentally healthy, to have a solid foundation, to be sustainable, to be co-operative and enjoyable, and to be reflective and enquiring. SER-RCF played a central role in developing the curriculum system of rehabilitation, education and psychology, and practice. ConclusionReshaping the undergraduate level curriculum system of education and rehabilitation based on RCF is not only the implementation of the construction concept of new medicine and new liberal arts, but also can effectively connect with the international standard of rehabilitation higher education.

Application of WHO rehabilitation competency framework in development of rehabilitation science education system and curriculum / 中国康复理论与实践

ObjectiveTo systematically analyze the application of World Health Organization rehabilitation competency framework (RCF) and its supporting guidelines in education system of rehabilitation science and curriculum development. MethodsBased on the conceptual framework of RCF and its supporting guidelines, the application of its areas and the modes were analyzed to construct the education system of rehabilitation science with reference to the framework of competency-based clinical medical education. ResultsThe education system of rehabilitation science was developed based on RCF. The competences for specific scenarios in rehabilitation were defined and investigated. A structured system of vocational qualification accreditation and occupational competency standards was constructed, as well as core education system and rehabilitation curricula in rehabilitation science, which helped to train competent rehabilitation workers. ConclusionThe construction of rehabilitation subspecialties, its education system and the development of a curriculum content system based on the RCF is an important way for the development of modern rehabilitation education. RCF theoretical framework and supporting tools provide a standardized and unified method and way for China's rehabilitation science higher education system and professional certification, career access and professional standards for rehabilitation personnel. The quality of rehabilitation science education and the professional development of rehabilitation personnel will also be improved in future.

Construction of basic rehabilitation training course for family doctor teams serving for people with disabilities based on WHO rehabilitation competency framework / 中国康复理论与实践

ObjectiveTo develop basic training courses for family doctor teams for people with disabilities. MethodsUtilizing the methods and theories of the World Health Organization (WHO) rehabilitation competency framework (RCF), and referring to the WHO universal health coverage global competency framework, the rehabilitation competency characteristics of family doctor teams for people with disabilities in community settings were analyzed, and a basic training course system for these teams based on the RCF was developed. Results and ConclusionBased on RCF, a competency framework for family doctor teams serving people with disabilities has been constructed. The objectives, content and training course system for basic rehabilitation training has been established.

Survey of rehabilitation competency of Chinese rehabilitation physicians using WHO rehabilitation competency framework / 中国康复理论与实践

ObjectiveTo investigate rehabilitation competence among trainers and trainees whom participated in the training program entitled National Training Program of Shortage Rehabilitation Physicians (NTPSRP) using World Health Organization rehabilitation competency framework (RCF). MethodsBased on RCF, a questionnaire was developed and administrated through network using Questionnaire Star. All the trainers and trainees who participated in NTPSRP were investigated in September, 2023. ResultsA total of 911 subjects were collected from 27 provinces, including 426 trainers (teachers) and 485 trainees (students). The average age of the teachers was older, with more years of work experience and professional experience in rehabilitation medicine. The degree and professional title of the teachers was also higher. The overall internal consistency reliability of the questionnaire was good (Cronbach's α = 0.988), and all the internal consistency reliability in five fields was good (Cronbach's α > 0.9). The five dimensional structure of RCF in the results was consistent with the prior model established by RCF theory. The self-ratings of all physicians in the five fields were higher than the median level, and was higher in the teachers than in the students [(3.42±0.68) vs. (2.73±0.80), P < 0.001]. Gender and years of experience in rehabilitation medicine were independent factors for the total score of the questionnaire. The total self-rating of female students was 9.65 points lower than that of the male (95%CI 4.386 to 14.914); and one more year in rehabilitation medicine would increase 1.78 points in self-rating (95%CI 1.140 to 2.419). ConclusionThe structure and content of RCF can be used to evaluate the competence of rehabilitation physicians. The teachers and students of NTPSRP are eligible to RCF. RCF-based evaluation can be used to guide the development of continuing education courses for rehabilitation professionals.

Development of traditional Chinese medicine rehabilitation curriculum based on World Health Organization rehabilitation competency framework / 中国康复理论与实践

ObjectiveTo develop a high-quality rehabilitation major curriculum using the World Health Organization rehabilitation competency framework (RCF), to improve the level of traditional Chinese medicine (TCM) rehabilitation major, to meet the requirements of competency-based education development. MethodsThe competence requirements of rehabilitation professionals of higher traditional TCM colleges and universities were analyzed using the theory and method of RCF. ResultsThe competency structure of TCM rehabilitation talents based on RCF was built, and the curriculum setting of TCM rehabilitation based on RCF was proposed. According to the characteristics of the educational environment of colleges and universities, a competency model suitable for undergraduate-level TCM rehabilitation major was established. ConclusionThe theory and methods of RCF are of great significance for the construction of competency-based education system of TCM rehabilitation major. Based on RCF, this study constructs the basic and practical curriculum system of TCM rehabilitation at the undergraduate level to promote the training of applied talents in TCM rehabilitation.

Application of Sendai Framework for Disaster Risk Reduction in Food Security During Flood Disaster in Malaysia: A Narrative Review

@#Disaster risk reduction (DRR) plays essential roles in ensuring food security to avoid adverse social, economic and financial implications to the disaster victims. This article aims to review existing DRR strategies in food security during flood disasters and recommend strategies that can be adapted into policies in Malaysia according to the Sendai Framework. Sendai Framework provides comprehensive, globally recognized priority themes in DRR while highlighting governmental and stakeholders’ responsibility. A literature review was carried out by searching available published literatures from online databases and selected information used in this review is taken from articles, journals, reports, national reports, news, and thesis regarding the topic from November 2021 to January 2022. This review revealed that DRR strategies of food security during flood disasters in Malaysia lack one out of 14 work areas in four priorities in the Sendai Framework, which is the national-level risk and vulnerability assessment system and tools. This article proposed 19 recommendations to improve eight work areas across all four priority areas to enhance national food security during flood disasters.

Construction and effectiveness evaluation of surgical complication monitoring mode based on medical record homepage data / 中华医院管理杂志

Objective:To explore the establishment of a surgical complication monitoring mode based on data on the medical record homepage, and analyze its impact on the trend of changes in surgical complication incidence.Methods:A monitoring mode of surgical complication was developed based on the " structure-process-results" framework by using surgical complication rates derived from performance appraisal for a tertiary general hospital in Guangzhou. The number of surgical complications and the number of discharged surgical patients was collected from the hospital from January 2019 to June 2022 through the home page collection system for performance appraisal of national tertiary public hospitals. Descriptive analysis was used to analyze the incidence of surgical complications, and Joinpoint regression was used to analyze the trend of changes in the incidence of surgical complications. Monthly percentage change ( MPC) and average monthly percentage change ( AMPC) were calculated. Results:Since the hospital began implementing the surgical complication monitoring mode in May 2021, the incidence of surgical complications had decreased from 2.55% in June 2021 to 0.82% in June 2022, with an MPC of -5.58% ( P=0.024), which was better than the changes from January 2019 to May 2021 ( MPC=0.18%, P=0.755). Conclusions:The surgical complication monitoring mode constructed by the hospital can effectively reduce the incidence of surgical complications, providing reference for optimizing hospital′s medical quality management process and decision-making mode.

A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy

The typical hallmark of tumor evolution is metabolic dysregulation. In addition to secreting immunoregulatory metabolites, tumor cells and various immune cells display different metabolic pathways and plasticity. Harnessing the metabolic differences to reduce the tumor and immunosuppressive cells while enhancing the activity of positive immunoregulatory cells is a promising strategy. We develop a nanoplatform (CLCeMOF) based on cerium metal-organic framework (CeMOF) by lactate oxidase (LOX) modification and glutaminase inhibitor (CB839) loading. The cascade catalytic reactions induced by CLCeMOF generate reactive oxygen species "storm" to elicit immune responses. Meanwhile, LOX-mediated metabolite lactate exhaustion relieves the immunosuppressive tumor microenvironment, preparing the ground for intracellular regulation. Most noticeably, the immunometabolic checkpoint blockade therapy, as a result of glutamine antagonism, is exploited for overall cell mobilization. It is found that CLCeMOF inhibited glutamine metabolism-dependent cells (tumor cells, immunosuppressive cells, etc.), increased infiltration of dendritic cells, and especially reprogrammed CD8+ T lymphocytes with considerable metabolic flexibility toward a highly activated, long-lived, and memory-like phenotype. Such an idea intervenes both metabolite (lactate) and cellular metabolic pathway, which essentially alters overall cell fates toward the desired situation. Collectively, the metabolic intervention strategy is bound to break the evolutionary adaptability of tumors for reinforced immunotherapy.

Interseccionalidade e transexualidade no processo discriminatório: uma revisão integrativa / Intersectionality and transsexuality in the process of discrimination: an integrative review / Interseccionalidad y transexualidad en el proceso discriminatorio: una revisión integradora

Objetivo: identificar na literatura acadêmica as principais discriminações interseccionais vividas por mulheres trans e discutir o seu processo de estabelecimento nesse grupo populacional. Método: estudo de revisão integrativa de literatura conduzida em duas bases e três bibliotecas virtuais durante o ano de 2021 e revisada em 2022. Foi realizada análise lexicográfica por meio do software IRAMUTEC. Resultados: foram identificados 486 manuscritos, selecionando-se 15 para análise. Emergiram três categorias analíticas: (1) Interseccionalidade como multiplicador de opressões, (2) Dificuldade de acesso ao cuidado e a precarização da saúde e (3) Necessidade de Políticas Públicas Específicas e o enfrentamento da InJustiça. Conclusão: as condições estruturais do racismo, sexismo, etnofobia e violências correlatas se sobrepõem, e na base da pirâmide discriminatória se encontram as mulheres transexuais negras. Pesquisas adicionais são necessárias para levar a melhores intervenções a esta população em risco de violência.

Objective: to identify, in the academic literature, the main intersecting discriminations experienced by trans women and to discuss process by which it is established related to this population group. Method: this integrative literature review study was conducted in two databases and three virtual libraries during 2021 and then revised in 2022. Lexicographic analysis was performed using the IRAMUTEC software. Results: 486 manuscripts were identified and 15 were selected for analysis. Three analytical categories emerged: (1) Intersectionality as a multiplier of oppression; (2) Difficulty in accessing care and increasingly precarious health; and (3) Need for specific public policies and addressing injustice. Conclusion: the structural conditions of racism, sexism, ethnophobia, and related violence overlap, and black transsexual women are at the base of the pyramid of discrimination. Additional research is needed to lead to better interventions for this population at risk of violence.

Objetivo: identificar en la literatura académica las principales discriminaciones interseccionales experimentadas por mujeres trans, así como discutir su proceso de implantación en este grupo poblacional. Método: estudio de revisión integradora de literatura realizado en dos bases de datos y tres bibliotecas virtuales durante el año 2021 y revisado en 2022. El análisis lexicográfico se realizó mediante el software IRAMUTEC. Resultados: se identificaron 486 manuscritos y se seleccionaron 15 para su análisis. Surgieron tres categorías de análisis: (1) Interseccionalidad como multiplicador de la opresión, (2) Dificultad de acceso a la atención y precarización de la salud, y (3) Necesidad de Políticas Públicas Específicas y el enfrentamiento a la InJusticia. Conclusión: las condiciones estructurales del racismo, el sexismo, la etnofobia y las violencias relacionadas se superponen, y en la base de la pirámide de discriminación se encuentran las mujeres negras transgénero. Se necesita investigaciones adicionales para conducir a mejores intervenciones para esta población en riesgo de violencia.